Pancreatic ductal adenocarcinoma (PDAC) is a rapidly progressing malignancy with a poor prognosis. Quercetin is a flavonoid compound with various biological benefits that can be extracted from Chinese herbs or daily foods. Quercetin has anticancer properties in various types of cancers. However, its therapeutic effects and potential mechanisms in PDAC have not been investigated extensively. Here, we confirmed the therapeutic effect of quercetin in PDAC using a mouse model. Based on high-throughput RNA sequencing (RNA-seq) and bioinformatic analysis, we propose that quercetin is involved in stromal infiltration of PDAC. Quercetin attenuates the activation of cancer-associated fibroblasts (CAFs) via tumor-stromal interaction. Meanwhile, we have identified two quercetin-related prognostic models for patients with PDAC. Finally, we proposed a downstream target of quercetin, the ITGB4 gene, which could be a potential therapeutic target for PDAC.
Journal of Food Biochemistry, Volume 2024, Issue 1, 2024. Read More
Related posts:
Effect of quercetin and Abelmoschus esculentus (L.) Moench on lipids metabolism and blood glucose through AMPK‐α in diabetic rats (HFD/STZ)
Bitter Hops Supplement Calocurb Associated with Craving and Hunger Reduction in Women
Antimicrobial Potential of Organic Phenolic Compounds from Wild Mushroom Extracts: Impact on Proliferation and Kinetic Growth of Multidrug‐Resistant Neisseria gonorrhoeae Strains
In Vivo and In Vitro Study on the Mechanism of Anticervical Cancer Effects of Corilagin in Mice
Dried Zingiber officinale Alleviates Dehydroepiandrosterone‐Induced Ovarian Granulosa Cell Apoptosis via the Reactive Oxygen Species‐Mediated Pathway
Chemical Composition and In Vitro and In Silico Biological Activities of Myrciaria tenella (DC.) O.Berg (Myrtaceae) Essential Oil from Brazil